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Degrees
- M.D., The Third Medical University, Changquing, China 1980
- M.S., The Third Medical University, Changquing, China 1984
- PhD, Academy of Medical Science, Beijing, China 1994
- Postdoctoral training, Thomas Jefferson University, Philadelphia 1989-1991
- Mammalian cells response to DNA double strand break including checkpoint activation and DNA repair
- Relationship between DNA damage response and metastasis
- Wang X, Khadpe J, Hu B, Iliakis G and Wang Y. An over-activated ATR/CHK1 pathway is responsible for the prolonged G2 accumulation in irradiated AT cells. J Biol. Chem., 278: 30869-30874, 2003.
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Wang H, Wang X, Iliakis G and Wang Y. Caffeine could not efficiently sensitize homologous recombination repair deficient cells to ionizing radiation-induced killing. Radiat. Res. 159: 420-425, 2003.
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Wang X, Wang H, Iliakis G and Wang Y. Caffeine-induced radiosensitization is independent of non-homologous end joining of DNA double strand breaks. Radiat. Res. 159: 426-432, 2003.
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Iliakis G, Wang Y, Guan J and Wang H. DNA damage checkpoint control in cells exposed to ionizing radiation. (Review) Oncogene, 22: 5834-5847, 2003.
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Wang X, Guan J, Hu B, Weiss RS, Iliakis G and Wang Y. Involvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiation. Nucleic Acids Res., 32: 767-775, 2004.
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Ottey M, Han S-Y, Druck T, Barnoski B, McCorkell K, Croce CM, Raventos-Suarez C, Fairchild C, Wang Y and Huebner K. Fhit deficient normal and cancer cells are mitomycin C and UVC resistant. Brit J Cancer. 91:1669-1677, 2004.
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Wand H-Y, Wang H-C, Powell SN, Iliakis G and Wang Y. ATR affecting cell radiosensitivity is dependent on homologous recombination repair but independent of non-homologous end joining. Cancer Res. 64:7139-7143, 2004
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Hu B, Han S-Y, Wang X, Ottey M, Potoczek MB, Dicker A, Huebner K and Wang Y. Involvement of the Fhit gene in the ionizing radiation-activated ATR/CHK1 pathway. J. Cell Physiol. 202: 518-523, 2005.
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Ren Q, Liu RH, Dicker A and Wang Y. CHK1 affects cell sensitivity to microtubule-targeted drugs. J Cell Physiol. 203:273-276, 2005.
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Wang H-Y, Hu B, Liu R and Wang Y. CHK1 affecting cell radiosensitivity is independent of non-homologous end joining. Cell Cycle 4: 300-303, 2005.
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Hu B, Wang H-Y, Wang X, Lu, H-R, Huang C, Powell SN, Huebner K and Wang Y. Fhit and CHK1 have opposing effects on homologous recombination repair. Cancer Res 65: 8613-8616, 2005.
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Wang, X., Hu, B., Weiss, RS and Wang Y. The effect of Hus1 on ionizing radiation sensitivity is associated with homologous recombination repair but is independent of non-homologous end-joining. Oncogene, 25: 1980-1983, 2006.
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Lu, H-R, Wang X and Wang, Y. Stronger DNA Damage-induced G2 Checkpoint due to Over-activated CHK1 in the Absence of PARP-1. Cell Cycle, 5: 2364-2370, 2006.
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Ishii, H., Wang, Y. and Huebner, K. A Fhit-ing role in the DNA damage checkpoint response. (Review), Cell Cycle, 6: 1044-1048. 2007.
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Wang, H., Wang, X. Zhang, PY and Wang, Y. The Ku-dependent non-homologous end-joining but not other repair pathway is inhibited by high-linear energy transfer ionizing radiation. DNA Repair, 7: 725-733, 2008.
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Lu, L. and Wang, Y. Immunoprecipitation alert: DNA binding proteins directly bind to protein A/G without any antibody as the bridge. Cell Cycle, 7: 417-418, 2008.
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Pichiorri, F., Ishii, H., Okumura, H., Trapasso, F., Wang, Y. and Huebner, K. Molecular parameters of genome instability: roles of fragile genes at common fragile sites. J Cell Biochem, 104:1525-33, 2008.
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Wang, H. and Wang, Y. Checkpoint response plays a more protective role in HZE particle-irradiated cells than in X ray-irradiated cells. Cell Cycle, Volume 7: 2444-2445, 2008.
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Liu, S., Zhang, P-Y, Wang, H., Wang, X., Lu, L. Gao, N., Rowe, PSN, Hu, B. and Wang, Y. MEPE/OF45 preventing CHK1 from ubiquitine-proteolysis depends on their interaction Submitted, 2008.
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Lu, L., Hu, B., Yu, F. and Wang, Y. Low dose radiation induced adapted effects on preventing HPRT mutation are Fhit independent. Submitted, 2008.
- Wang, H, Liu, S, Zhang, P-Y, Naidu, M, Wang, H-C and Wang, Y. S-phase cells are more sensitive to high linear energy transfer radiation, Submitted, 2008.
Book Chapters
- Wang Y, Wang H. Chapter "CHK1 kinase activity assay" in the Book of Methods and Protocols, Checkpoint Controls and Cancer, (Edited by Axel H. Schönthal, Ph.D.), PP: 143-151, The Humana Press Inc, 2004.
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