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Link to Dr. Vertino's Laboratory Website

Education and Degrees

• Ph.D., State University of New York, Buffalo, New York, 1990
• B.S., State University of New York, Stony Brook, New York, 1983

Training

• Postdoctoral Fellow, John Hopkins Oncology Center, Baltimore, Maryland, 1990-6

Special Interests

• Role of DNA methylation and epigenetics in human cancer
• TMS1 gene's role in apoptosis and breast carcinogenesis

Committee Memberships

• California Cancer Research Program, Grant Review Panel, Prevention Study Section, 2000

• Johns Hopkins Prostate Cancer SPORE program, External Scientific Advisory Board, 2002-5

• DOD/Congressionally Directed Medical Research Program in Breast Cancer, Pathobiology 5 Study Section, 2003

• National Institutes of Health, Chemical Pathology Study Section,  2003-Present

Selected Recent Publications

• McConnell BB, Vertino PM.  TMS1/ASC:  the cancer connection.  Apoptosis 9(1): 5-18; 2004.
• Levine JJ, Stimson KM, Vertino PM.  Effect of methylation on the expression of TMS1/ASC in human breast cancer cells. Oncogene 22: 3475-85; 2003.
• Feltus FA, Lee EK, Costello JF, Plass C, Vertino PM.  Predicting aberrant CpG island methylation.  Proceedings of the National Academy of Sciences 100: 12253-8; 2003.
• Vertino PM, Sekowski JA, Coll JM, Applegren N, Han S, Malkas LH. DNMT1 is a component of a multiprotein DNA replication complex. Cell Cycle 1:  416-23; 2002.
• Costello JF, Vertino PM.  Methylation matters:  a new spin on maspin. Nature Genetics 37: 119-20; 2002.
• Stimson KM, Vertino PM.  Methylation-mediated silencing of TMS1/ASC is accompanied by histone hypoacetylation and CpG-island localized changes in chromatin architecture. Journal of Biological Chemistry 277: 4951-8; 2002.
• Marfatia KA, Harreman MT, Vertino PM, Corbett AH. Identification and characterization of the human MOG1 gene. Gene 266:  45-56; 2001.
• McConnell BB, Vertino PM.  Activation of a caspase-9 mediated apoptotic pathway by subcellular redistribution of the novel CARD protein, TMS1. Cancer Research 60: 6243-7; 2000.
• Conway KE, McConnell BB, Bowring CM, Donald CD, Warren ST, Vertino PM.  TMS1, a novel proapoptotic CARD protein, is a target of methylation-associated gene silencing in human breast cancer.  Cancer Research 60: 6236-42; 2000.
• Vertino PM.  Eukaryotic DNA methyltransferases.  In: S-adenosylmethionine-dependent Methyltransferases: Structures and Functions. Cheng X, Blumenthal RM (eds).  Pp. 341-72.  World Scientific, River Edge, NJ, 1999.