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Hui-Kuo George Shu, M.D., Ph.D.

Associate Professor

Education and Degrees

·        1983-1986, B.A., Washington University.

·        1986-1991, Ph.D., Case Western Reserve University, Advisor: Hsing-Jien Kung, PhD.

·        1986-1993, M.D., Case Western Reserve University.

Certification

  • American Board of Radiology, Radiation Oncology, 1999

Training

·        University Hospitals of Cleveland, Intern in Medicine, 07/1993-06/1994.

·        UCSF, Resident in Radiation Oncology, 07/1994-06/1999.

·        UCSF, Brain Tumor Research Center, Research Fellow, 07/1995-06/1997

Special Interests

  • My focus is on the study of brain tumors.  Clinically, I hope to improve therapy by participating in various cooperative group trials.  In the lab, I hope to gain a greater understanding of how malignant gliomas arise and how they respond to inhibition of the epidermal growth factor receptor.

Selected Recent Publications

o   Tykocinski, M.L., Shu, H.-K.G., Ayers, D.J., Walter, W.I., Getty, R.K., Groger, C.A., Hauer, and Medof, M.E., 1988, Glycolipid Reanchoring of T-Lymphocyte Surface Antigen CD8 Using the 3’ End Sequence of Decay-Accelerating Factors mRNA, Proc. Natl. Acad. Sci. USA, 85, 3555-3559.

o   Hambor, J.E., Hauer, C.A., Shu, H.-K.G., Groger, R.K., Kaplan, D.R., and Tykocinski, M.L., 1988, Use of Epstein-Barr Virus Episomal Replicon for Anti-Sense RNA-Mediated Gene Inhibition in a Human Cytoxic T-Cell Clone, Proc. Natl. Acad. Sci. USA, 85, 4010-4014.

o   Pelley, R.J., Maihle, N.J., Boerkoel, C., Shu, H.K.G., Carter, C., Moscovici, and Hung, H.-J., 1989, Disease Tropism of c-erbB: Effects of Carboxyl-Terminal Tyrosine and Internal Mutations on Tissue-Specific Transformation, Proc. Natl. Acad. Sci. USA, 86, 7164-7168.

o   Kung, H.-J., Pelley, R.J., Shu, H.K.G., Maihle, M.A., Raines, Carter, T.H., Boerkoel, C., Moscovici, G., and Moscovici, C., 1990, Retroviral Insertional Mutagenesis: The Making of a Receptor-Oncogene, Develop. Biol. Standard, 72, 139-144.

o   Shu, H.-K.G., Pelley, R.J. and Kung, H.-J., 1990, Tissue Specific Transformation by epidermal growth factor receptor: A Single Point Mutation within the ATP-Binding Pocket of the erbB Product Increases its Intrinsic Kinase Activity and Activates its Sarcomagenic Potential, Proc. Natl. Acad. Sci. USA, 87, 9103-9107.

o   Shu, H.-K.G., Pelley, R.J., and Kung, H.-J., 1991, Dissecting the Activating Mutations in v-erbB of AEV-R, J. Virol., 65, 6173-6180.

o   Shu, H.-K.G., Chang, C.-M., Ravi, L., Ling, L., Castellano, C.M., Walter, E., Pelley, R.J., and Kung, H.-J., 1994, Modulation of erbB Kinase Activity and Oncogenic Potential by Single Point Mutations in the Glycine Loop of the Catalytic Domain, Mol. Cell. Biol., 14, 6868-6878.

o   Chang, C.-M., Shu, H.-K.G., Ravi, L., Pelley, R.J., Shu, H., and Kung, H.-J., 1995,A Minor Tyrosine Phosphorylation Site Localized within the CAIN Domain Plays a Critical Role in Regulating Tissue-Specific Transformation by erbB Kinase, J. Virol., 69, 1172-1180.

o   Chang, C.-M., Shu, H.-K.G., and Kung, H.-J.  Disease Specificity of Kinase Domain: Src Catalytic Domain Converts erbB into a Sarcoma Oncogene, 1995, Proc. Natl. Acad. Sci. USA, 92, 3928-3932.

o   Shu, H.-K.G., Sneed, P.K., Shiau, C.Y., McDermott, M.W., Lamborn, K.R., Park, E., Ho, M., Petti, P.L., Smith, V., Verhey, L.J.,Wara, W.M., Gutin, P.H., and Larson, D.A., 1996, Factors Influencing Survival after Gamma Knife Radiosurgery for Patients with Single and Multiple Brain Metastases, Cancer J. from Sci. Amer., 2, 335-342.

o   Shiau, C.Y., Sneed, P.K., Shu, H.-K.G., Lamborn, K.R., McDermott, M.W., Chang, S., Nowak, P., Petti, P.L., Smith, V., Verhey, L.J., Ho, M., Park, E., Wara, W.M., Gutin, P.H., and Larson, D.A., 1997, Radiosurgery for Brain Metastases: Relationship of Dose and Pattern of Enhancement to Local Control, Int. J. Rad. Onc. Bio. Phys., 37, 375-383.

o   Seung, S.K., Sneed, P.K., McDermott, M.W., Shu, H.-K.G., Leong, S., Chang, S., Petti, P.L., Smith, V., Verhey, L.J., Wara, W.M., Phillips,. T.L., and Larson, D.A., 1998, Gamma-Knife Radiosurgery for Melanoma Brain Metastases, Cancer J. from Sci. Amer., 4, 103-109.

o   Florio, M., Hernandez, M.C., Yang, H., Shu, H.-K.G., Cleveland, J.L., and Israel, M.A., 1998, Id2 Promotes Apoptosis by a Novel Mechanism Independent of Dimerization to Basic Helix-Loop-Helix Factors, Mol. Cell Bio., 18, 5435-5444.

o   Shu, H.-K.G., Kim, M.M., Furman, F., Julin, C.M., and Israel, M.A., 1998, The Intrinsic Radioresistance of Glioblastoma-Derived Cell Lines is Associated with a Failure of p53 to Induce p21BAX Expression, Proc. Natl. Acad. Sci. USA, 95, 14453-14458.

o   Shu, H.-K.G., Julin, C.M. , Furman, F., Yount, G.L., Haas-Kogan, D., and Israel, M.A., 2000, Overexpression of E2F-1 in Glioma-Derived Cell Lines Induces a p53-Independent Apoptosis that is Further Enhanced by Ionizing Radiation, Neuro-Oncology, 2, 16-21.

o   Sultanem, K., Shu, H.-K., Xia, P., Akazawa, C., Quivey, J.M., Verhey, L.J., and Fu, K.K., 2000, Three-Dimensional Intensity-Modulated Radiotherapy in the Treatment of Nasopharyngeal Carcinoma: The University of California-San Francisco Experience, Int. J. Rad. Onc. Bio. Phys., 48, 711-722.

o   Le, Q.-T., Takamiya, R., Shu, H.-K., Smitt, M., Singer, M., Terris, D. J., Fee, W. E., Goffinet, D. R., and Fu, K.K., 2000, Treatment Results of Carcinoma In Situ of the Glottis:An Analysis of 82 Cases, Arch. Otolaryngol. Head Neck Surg., 126, 1305-1312.

o   Shu, H.-K.G., Lee, T.T., Vigneault, E., Xia, P., Pickett, B., Phillips, T.L., and Roach, M., 2001, Toxicity Following High-Dose Three-Dimensional Conformal and Intensity-Modulated Radiation Therapy for Clinically Localized Prostate Cancer, Urology, 57, 102-107.

o   Lee, T.T., Everett, D.L., Shu, H.-K., Jahan, T.M., Roach, M., Speight, J.L.,Cameron, R.B., Phillips, T.L.,Chan, A. and Jablons, D.M., 2002, Radical Pleurectomy/Decortication and Intraoperative Radiotherapy Followed by Conformal Radiation with and without Chemotherapy for Malignant Pleural Mesothelioma, J. Thorac. Cardiovasc. Surg., 124, 1183-1189.

o   Chen, C., Shu, H.-K.G., Goldwein, J.W., Womer, R.B., and Maity A., 2003, Volumetric considerations in radiotherapy for pediatric parameningeal rhabdomyosarcomas, Int. J. Rad. Onc. Bio. Phys., 55, 1294-1299.

o   Li, B., Chang, C.-M., Yuan, M., McKenna, W.G., and Shu, H.-K.G., 2003, Resistance to small molecule inhibitors of epidermal growth factor receptor in malignant gliomas, Cancer Res., 63, 7443-7450.

o   Stripp, D.C.H., Maity, A., Janss, A.J., Belasco, J.B., Tochner, Z.A., Goldwein, J.W., Moshang, T., Rorke, L.B., Phillips, P.C., Sutton, L.N.,  and Shu, H.-K.G., 2004, Surgery with or without radiation therapy in the management of craniopharyngiomas in children and young adults, Int. J. Rad. Onc. Bio. Phys., 58, 714-720.

o   Maity, A., Shu, H.-K.G., Janss, A.J., Belasco, J.B., Rorke, L.B., Phillips, P.C., Sutton, L.N., and Goldwein, J.W., 2004, Craniospinal Radiation in the Treatment of Biopsy Proven Intracranial Germinomas: Twenty-five years experience in a single center, Int. J. Rad. Onc. Bio. Phys., 58, 1165-1170.

o   Li, B., Yuan, M., Kim, I.-A., Chang, C.-M., Bernhard, E.J.., and Shu, H.-K.G., 2004, Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin, Oncogene, 26, 4594-4602.

o   Bucci, M.K., Maity, A., Janss, A.J., Belasco, J.B., Fisher, M.J., Tochner, Z.A., Rorke, L.B., Sutton, L.N., Phillips, P.C., and Shu, H.-K.G., 2004, Near complete surgical resection predicts a favorable outcome in pediatric non-brainstem, malignant gliomas: Results from a single center in the MRI era, Cancer, 15, 817-824.

o   Maity, A., Shu, H.-K.G., Judkins, A.R., Fisher, M.J., Dwyer-Joyce, L.E.A., and Vaughn, D.J., 2004, Testicular seminoma sixteen years after treatment for CNS germinoma, J. Neuro-oncology, 70, 83-85.

o   Pore, N., Liu, S., Shu, H.-K., Li, B., Haas-Kogan, D., Stokoe, D., Milanini-Mongiat, J., Pages, G., O’Rourke, D.M., Bernhard, E. and Maity, A., 2004, Sp1 is involved in Akt-mediated induction of VEGF expression through a HIF-1 independent mechanism, Molecular Biology of the Cell, 15, 4841-4853.

o   Fisher, M.J., Lange, B.J., Needle, M.N., Janss, A.J., Shu, H.-K.G., Adamson, P.C. and Phillips, P.C., 2004, Amifostine for children with medulloblastoma treated with cisplatin-based chemotherapy, Pediatric Blood and Cancer, 43, 780-784.

o   Maity, A., Shu, H.-K.G., Tan, J., Ruffer, J., Sutton, L.N., Tochner, Z.A., and Lustig, R., 2004, Treatment of pediatric intracranial arteriovenous malformations with linear accelerator based stereotactic radiosurgery: the University of Pennsylvania experience, Pediatric Neurosurgery, 40, 207-214.

 

o   Pore, N., Jiang, Z., Shu, H.-K., Bernhard, E., Kao, G.D., and Maity, A., 2006, AKT activation can augment hypoxia-inducible factor-1 alpha expression by increasing protein translation through a mammalian Target Of Rapamycin-independent pathway, Molecular Cancer Research, 4, 471-479.