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Education and Degrees

• Ph.D., Brandeis University, Waltham, Massachusetts, 1981
• B.S., Nanyang Technological University, Singapore, 1976

Training

• Research Associate, Department of Biochemistry, University of Wisconsin, Madison, Wisconsin, 1981-3

Selected Recent Publications

• Hashimoto M, Moshi MA, Imhoff B, Kow YW.  Hu protein of Escherichia coli has a role in the repair of closely opposed lesions in DNA.  Journal of Biological Chemistry 278: 28501-7; 2003.

• Kroeger KM, Hashimotoa M, Kow YW, Greenberg M.  Cross-linking of 2-deoxyribonolactone and its b-elimination product by base excision repair enzymes.  Biochemistry 42: 2449-55; 2003.

• Kelley MR,  Kow YW, Wilson III DM.  Disparity between DNA base excision repair in yeast and mammals:  translational implications.  Cancer Research 63:  540-54; 2003.

• Hazra TK, Izumi T, Kow YW, Mitra S.  The discovery of a new family of mammalian enzymes for repair of oxidatively damaged DNA and its physiological implications.  Carcinogenesis 24:  155-7; 2003.  

• Kow YW.  Repair of oxidative deaminated bases in DNA.  Free Radical Biology and Medicine 33: 886-93; 2002.

• Hazra TK, Kow YW, Hatahet Z, Imhoff B, Boldogh I, Mokkapati SK, Mitra S,  Izumi T.  Identification and characterization of a novel human DNA glycosylase for repair of cytosine derived lesions.  Journal of Biological Chemistry 277: 30417-20; 2002.

• Hazra TK, Izumi T, Boldogh I, Imhoff B, Kow YW, Jaruga P, Dizdaroglu M, Mitra S.   Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA.  Proceedings of the National Academy of Science (USA) 99:  3523-8; 2002.

• Hashimoto M, Greenberg MM, Kow YW, Hwang JT, Cunningham RP.  The 2-deoxyribonolactone lesion produced in DNA by neocarzinostatin and other DNA damaging agents forms crosslinks with the base-excision repair enzyme endonuclease III.  Journal of the American Chemical Society 123: 3161-2; 2001.

• Hashimoto M, Donald CD, Yannone SM, Chen DJ, Roy R, Kow YW.  A possible role of Ku in mediating sequential repair of closely opposed lesions.  Journal of Biological Chemistry  276: 12827-31; 2001.

• Rabow L, Venkataraman R, Kow YW.  Mechanism  of action of Escherichia coli formamidopyrimidine n-glycosylase:  role of K155 in substrate binding and product release.  Progress in Nucleic Acid Research and Molecular Biology 68: 223-34; 2001.

• Venkhataraman R,  Donald CD,  Roy R, You HJ,  Doetsch PW, Kow YW.  Enzymatic processing of DNA containing tandem dihydrouracil by endonucleases III and VIII.  Nucleic Acids Research 29: 407-14; 2001.

• Liu J, He B, Qing H, Kow YW.  A deoxyinosine specific endonuclease from hyperthermophile,  Archaeoglobus fulgidus: a homolog of Escherichia coli endonuclease V.  Mutation  Research 461: 169-77; 2000.

• Hazra TK, Izumi T, Venkataraman R, Kow YW, Dizdaroglu M, and Mitra S.  Characterization of a novel 8-oxoguanine-DNA glycosylase in Escherichia coli and its identification as endonuclease VIII.  Journal of Biological Chemistry  275: 27762-7; 2000.

• Kow YW, Akindate D.  Detection of abasic sites and oxidative DNA base damages using an ELISA-like assay.  In:  Methods:  A Companion to Methods in Enzymology,   Doetsch PW (ed).  22: 164-9.  Academic Press,  New York, NY, 2000.

• He B, Qing H, Kow YW.  Deoxyxanthosine in DNA is repaired by Escherichia coli endonuclease V.  Mutation Research 459: 109-14; 2000.

• Bazar LS, Collier GB, Vanek PG, Siles BA, Kow YW, Doetsch PW, Cunningham RP, Chirkjian JG.  Mutation identification DNA analysis system (MIDAS) for detection of known mutations.  Electrophoresis 20: 1141-8; 1999.

• Milligan JR, Aguilera JA, Nguyen TTD, Ward JF, Kow YW, He B, Cunningham RP.  Yield of DNA strand breaks after base oxidation of plasmid DNA.  Radiation Research 151: 334-42; 1999.