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Ashesh Jani, M.D.
Associate
Professor of Radiation Oncology
Education
and Degrees
- 1989, Bachelor of Science (B.S.), Electrical
Engineering, University of Illinois (at Urbana-Champaign)
- 1991, Master of Science (M.S.), Electrical and
Computer Engineering, University of Illinois (at Urbana-Champaign)
- 1995, Doctor of Medicine (M.D.), University of
Illinois College of Medicine (at Chicago)
Certification
- American Board of Radiology, Radiation Oncology, 2001
Training
- 1995-1996: Rush-Presbyterian-St. Luke's Medical
Center (RPSLMC), Chicago, IL,
Intern (Preliminary Year Resident), Department of Internal Medicine
- 1996-2000: University of Chicago Hospitals
Categorical Resident, Department of Radiation and Cellular
Oncology [Chief Resident, 07/1999-06/2000]
[NIH-NCI/NRSA Research Fellow, 07/1996-06/1997]
Special
Interests
I am an academic radiation
oncologist, who comes from an electrical engineering background, who is
interested in understanding (a) the patient, disease, and treatment factors
influencing clinical outcomes, (b) the impact of recently developed
technologies on these outcomes, and (c) the design of new technologies
[particularly in visualization and radiation treatment planning/delivery]
to improve these outcomes.
Selected
Recent Publications
o
JJ Sychra, DG Pavel, Y Chen, and A Jani. 1994. "The Accuracy of
SPECT Brain Activation Images. Part I: Propagation of Registration
Errors." Medical Physics. 21(10): 1585-1590.
o
AB Jani and JJ Sychra.
1995. "MR Image Classification Algorithms for Neurosurgical and
Stereotactic Radiosurgical Trajectory Planning
and Volumetric Analysis." Neurological Research. 17(1): 17-23.
o
AB Jani, CA Pelizzari,
GTY Chen, RP Grzeszczuk, and S Vijayakumar. 1997. "Interactive Tool for
Evaluating the Utility of Volume-Rendered Images Versus
Sagittal Plane-Picked Images of the Prostate for
Radiotherapy Treatment Planning." RSNA Electronic Journal. 1(1),
http://ej.rsna.org [online journal
– no page numbers].
o
AB Jani, CA Pelizzari,
GTY Chen, and RP Grzeszcuk. 1998. "Accuracy
of Object Depiction and Opacity Transfer Function Optimization in CT
Volume-Rendered Images." Journal of Computer Assisted Tomography.
22(3): 459-470.
o
JS Lee, AB Jani, CA Pelizzari,
DJ Haraf, RR Weichselbaum,
and GTY Chen. 1999. "Volumetric Rendering of Head and Neck CT Data for
Treatment Planning." International Journal of Radiation Oncology,
Biology, and Physics. 44(3): 693-703.
o
AB Jani, M Chen, F Vaida,
L Ignacio, A Awan, RR Weichselbaum, and S Vijayakumar.
1999. "PSA-Based Outcome Analysis After
Radiation Therapy for Prostate Cancer: a New Definition of Biochemical
Failure After Intervention." Urology. 54: 700-705.
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AB Jani, CA Pelizzari,
GTY Chen, JC Roeske, RJ Hamilton, L Macdonald, F Bova, KR Hoffmann, and PA Sweeney. 2000. "Volume
Rendering Quantification Algorithm for Reconstruction of CT Volume Rendered
Structures: I. Cerebral Arteriovenous
Malformations." IEEE Transactions on Medical Imaging. 19(1): 12-24.
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AB Jani, PP Connell, VJ Vesich,
KM O'Brien, and LM Chen. 2000. "An Analysis of the Impact of Adjuvant
Chemotherapy for Invasive Carcinoma of the Esophagus." American
Journal of Clinical Oncology (Cancer Clinical Trials). 23(6): 544-548.
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PP Connell, L Ignacio, D Haraf,
AM Awan, H Halpern, I Abdalla, J Nautiyal, AB Jani,
RR Weichselbaum, and S Vijayakumar.
2001. “Equivalent Racial Outcome Following Conformal Radiotherapy for
Prostate Cancer: A Single Departmental Experience.” Journal of Clinical
Oncology. 19(1): 54-61.
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A Jani and N Vogelzang.
2001. “Re: Neoadjuvant Hormonal Ablative Therapy Before Radical Prostatectomy: A Review. Is it Indicated?” Journal of Urology. 166(2): 631-632.
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AB Jani, F Vaida, G
Hanks, S Asbell, O Sartor, JW Moul,
M Roach, D Brachman, U Kalokhe,
R Muller-Runkel, P Ray, L Ignacio, A Awan, RR Weichselbaum, and S Vijayakumar. 2001. "The Changing ‘Face’ and
Different ‘Countenances’ of Prostate Cancer: Racial and Geographic
Differences in PSA, Stage, and Grade Trends in the PSA Era.” International
Journal of Cancer (Radiation Oncology Investigations). 96(6): 363-371.
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I Abdalla, L Ignacio,
F Vaida, M Chen, A Awan, A Jani, C Mamo, RR Weichselbaum, and S Vijayakumar.
2002. “Evolution of Toxicity after Conformal Radiotherapy for Prostate
Cancer.” Prostate Cancer and Prostatic Diseases. 5(4): 296-303.
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AB Jani, A Basu, R Heimann, and S
Hellman. 2003. “Sentinel Node versus Axillary
Node Dissection for Early Stage Breast Cancer: A Comparison Using a
Utility-Adjusted Number Needed to Treat (NNT) Analysis.” Cancer. 97(2):
359-366.
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AB Jani, CM Hand, CA Pelizzari,
JC Roeske, L Krauz, and
S Vijayakumar. 2003. “Biological Effective versus
Conventional Dose Volume Histograms Correlated with Late Gastrointestinal
and Genitourinary Toxicity after External Beam Radiotherapy for Prostate
Cancer: A Matched-Pair Analysis.” BMC Cancer. 3(16) [online – no page numbers].
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J Levitsky, JJ Hong,
AB Jani, and ED Ehrenpreis. 2003. “Oral Vitamin A
Therapy for a Patient with a Severely Symptomatic Post-Radiation Anal
Ulceration: Report of a Case.” Diseases of the Colon and Rectum. 46(5):
679-682.
o AB Jani.
2003. “Organ Motion and IMRT in Prostate Cancer Therapy [Re: Reduction
in Acute Morbidity using Hypofractionated
Intensity Modulated Radiotherapy Assisted with a Fluoroscopic Real-time
Tumor Tracking System for Prostate Cancer: Preliminary results of a Phase
I/II Study].” The Cancer Journal. 9(4): 244-246..
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AB Jani, A Basu, I Abdalla, L Krauz, PP Connell, and S Vijayakumar.
2003. “The Impact of Hormone Therapy When Combined with External Beam Radiotherapy
for Early-Stage, Intermediate- or High-Risk Prostate Cancer.” American
Journal of Clinical Oncology (Cancer Clinical Trials). 26(4): 382-385.
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AB Jani, J Kao, and S Hellman. 2003. “Hormone
Therapy Adjuvant to External Beam Radiotherapy for Locally Advanced
Prostate Cancer: A Utility-Adjusted Number-Needed to Treat (NNT) Analysis.”
Cancer. 98(11): 2351-2361.
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R Singh, H Al-Hallaq,
CA Pelizzari, GP Zagaja,
AA Chen, and AB Jani. 2003. “Dosimetric Quality
Endpoints for Low-Dose-Rate Prostate Brachytherapy
Using Biological Effective Dose (BED) vs. Conventional Dose.” Medical Dosimetry. 28(4): 255-259.
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AB Jani, D Spelbring,
R Hamilton, MJ Blend, CA Pelizzari, C Brendler, L Krauz, S Vijayakumar, B Sapra, and RR Weichselbaum. 2004. “Impact of Radioimmunoscintigraphy
on Definition of Clinical Target Volume for Radiotherapy after
Prostatectomy.” Journal of Nuclear Medicine. 45(2): 238-246.
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J Kao, J Turian, A Meyers, RJ Hamilton, B Smith, S Vijayakumar,
and AB Jani. 2004. “Sparing of the Penile Bulb and Proximal Penile
Structures with Intensity Modulated Radiation Therapy for Prostate Cancer.”
British Journal of Radiology. 77(914): 129-136.
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AB Jani, CM Hand, AE Lujan, JC Roeske, GP Zagaja, S Vijayakumar, and CA Pelizzari.
2004. “Biological Effective Dose for Comparison and Combination of External
Beam and Low-Dose Rate Interstitial Brachytherapy
Prostate Cancer Treatment Plans.” Medical Dosimetry.
29(1): 42-48.
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AB Jani, MJ Blend, R Hamilton, C Brendler, CA Pelizzari, L Krauz, S Vijayakumar, B Sapra, A Awan, and RR Weichselbaum. 2004. “The Influence of Radioimmunoscintigraphy on Post-Prostatectomy
Radiotherapy Treatment Decision-Making.” Journal of Nuclear Medicine.
45(4): 571-578.
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AB Jani, LC Myrianthopoulos,
and S Vijayakumar. 2004. “The Application of NNT
(Number Needed to Treat) to Clinical Problems in Radiotherapy.” Cancer
Investigation. 22(2): 262-270.
o MT
Milano, SJ Chmura, MC Garofalo,
C Rash, JC Roeske, O Kwon, PP Connell, AB Jani,
and R Heimann. 2004. “Intensity
Modulated Radiation Therapy (IMRT) in the Treatment of Pancreatic and Bile
Duct Malignancies: Toxicity and Clinical Outcome.” International Journal of
Radiation Oncology, Biology, and Physics. 59(2): 445-453.
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AB Jani, A Al-Qamari, B Sapra, L Krauz, A Awan, M Kocherginsky, and D Gillen. 2004. “Analysis of Prostate
Specific Antigen Rebound Interval in Prostate Cancer Patients Receiving
Hormones and External Beam Radiotherapy.” Clinical Prostate Cancer. 3(1):
43-48.
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J Kao, AB Jani, and S Vijayakumar. 2004. “Is there an Association between Multiple
Myeloma and Prostate Cancer?” Medical Hypotheses. 63(2): 226-231.
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AB Jani, MJ Blend, R Hamilton, C Brendler, CA Pelizzari, L Krauz, B Sapra, S Vijayakumar, A Awan, and RR Weichselbaum. 2004. “Radioimmunoscintigraphy
for Post-Prostatectomy Radiotherapy: Analysis of Toxicity and Biochemical
Control.” Journal of Nuclear Medicine. 45(8): 1315-1322.
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AB Jani, M Sokoloff, A Shalhav, and W Stadler. 2004. “Androgen Ablation Adjuvant to
Post-Prostatectomy Radiotherapy: A Complication-Adjusted Number-Needed to
Treat Analysis.” Urology. 64(5): 976-981.
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WH Hall, R Ramachandran,
S Narayan, AB Jani, and S Vijayakumar.
2004. “An Electronic Application for Rapidly Calculating Charlson Comorbidity Score.”
BMC Cancer. 4(1): 94.
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KD Chi, ED Ehrenpreis,
and AB Jani. 2005. “Accuracy and Reliability of the Endoscopic
Classification of Chronic Radiation-Induced Proctopathy
using a Novel Grading Method.” Journal of Clinical Gastroenterology. 39(1):
42-46.
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ME Lacouture, JM
Baron, AB Jani, AE Laumann, and K Soltani. 2005. “Treatment of
Radiation-Relapsing Primary Cutaneous B-Cell
Lymphoma with Anti-CD20 Monoclonal Antibody.” Clinical and Experimental Dermatology. 30(1):
46-48.
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ED Ehrenpreis, A Jani, J Levitsky, J Ahn, and J Hong. 2005. “A Prospective, Randomized, Double-Blind,
Placebo-Controlled Trial of Retinol Palmitate
(Vitamin A) for Symptomatic Chronic Radiation Proctopathy.”
Diseases of the Colon and Rectum. 48(1): 1-8.
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AB Jani, J Gratzle, E Muresan, and MK Martel. 2005. “Impact on Late Toxicity
of using Transabdominal Ultrasound for Prostate
Cancer Patients Treated with Intensity Modulated Radiotherapy.” Technology
in Cancer Research and Treatment. 4(1): 115-120.
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WH Hall, AB Jani, JK Ryu,
S Narayan, S Vijayakumar.
2005. “The Impact of Age and Comorbidity on Survival
Outcomes and Treatment Patterns in Prostate Cancer.” Prostate Cancer and
Prostatic Diseases. 8(1):22-30..
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AB Jani, J Kao, R Heimann,
and S Hellman. 2005. “Hormone Therapy Adjuvant to External Beam
Radiotherapy for Early Prostate Cancer: A Complication-Adjusted
Number-Needed to Treat (NNT) Analysis.” International Journal of Radiation
Oncology, Biology, and Physics. 61(3): 687-694.
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AB Jani, J Gratzle, E Muresan, K Farrey, and MK
Martel. 2005. “Analysis of Acute Toxicity with the Use of Transabdominal Ultrasound for Prostate Positioning
during Intensity-Modulated Radiotherapy Treatment.” Urology. 65(3):
504-508.
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AB Jani and J Kao. 2005. “Adjuvant versus
Salvage Post-Prostatectomy Radiotherapy: A Complication-Adjusted Number
Needed to Treat Analysis.” Cancer. 103(9): 1833-1842.
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AB Jani, SD Parikh, S Vijayakumar,
and J Gratzle. 2005. “Analysis of the Influence
of Age on Acute and Chronic Radiotherapy Toxicity in Treatment of Prostate
Cancer.” Urology. 65(6): 1157-1162.
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AB Jani, JS Irick, and
C Pelizzari. 2005. “Opacity Transfer Function
Optimization for Volume Rendered Computed Tomography Images of the
Prostate.” Academic Radiology. 12(6): 761-770.
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AB Jani and J Gratzle.
2005. “Analysis of the Impact of Age
and Race on Prostate Cancer Biochemical Control after Radiotherapy in
Different Prostate Cancer Settings.” Urology. 66(1): 124-129.
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AB Jani, J Gratzle,
and M Myers. 2005. “Impact of Hormone Therapy on Acute Radiotherapy
Toxicity in the Treatment of Prostate Cancer.” Prostate Cancer and
Prostatic Diseases. 8(3): 224-228.
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A Su, C Reft, C Rash,
J Price, and AB Jani. 2005. “A Case Study of Radiotherapy Planning for a
Bilateral Metal Hip Prosthesis Prostate Cancer Patient.” Medical Dosimetry. 30(3): 169-175.
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AB Jani and J Gratzle.
2005. “Late Radiotherapy Toxicity after Prostate Cancer Treatment:
Influence of Hormonal Therapy.” Urology. 66(3): 566-570.
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AB Jani. 2005.“The
Significance of Symptomatic Recurrence after Prostate Radiotherapy.”
American Journal of Oncology Review. 4 (9 Suppl
11): 29-30.
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MT Milano, AB Jani, KJ Farrey,
C Rash, R Heimann, and SJ Chmura.
2005. “Intensity-Modulated Radiation Therapy (IMRT) in the Treatment of
Anal Cancer: Toxicity and Clinical Outcome.” International Journal of
Radiation Oncology, Biology, and Physics. 63(2): 354-361.
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V Damerla, S Packianathan, PS Boerner, AB
Jani, S Vijayakumar, and V Vijayakumar.
2005. “Recent Developments in Nuclear Medicine in the Management of Bone
Metastases: A Review and Perspective.” American Journal of Clinical
Oncology (Cancer Clinical Trials). 28(5): 513-520.
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AB Jani, A Su, and MT
Milano. 2006. “Intensity Modulated versus Conventional Pelvic Radiotherapy
for Prostate Cancer: Analysis of Acute Toxicity.” Urology. 67(1): 147-151.
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A Su, MJ Blend, D Spelbring,
RJ Hamilton, and AB Jani. 2006. “Post-prostatectomy Target-Normal Structure
Overlap Volumes Using Computed Tomography and Radioimmuno-scintigraphy
Images for Radiotherapy Treatment Planning.” Clinical Nuclear Medicine. 31(3): 139-144.
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AB Jani. 2006. “Approaching Clinical Problems in
Prostate Cancer Radiotherapy Using the Number Needed to Treat (NNT)
Technique.” Cancer Investigation. 24(3):
318-327.
o AB Jani,
JM Feinstein, R Pasciak, S Krengel,
and RR Weichselbaum. 2006.
“The Role of External Beam Radiotherapy with Low Dose Rate Brachytherapy in the Treatment of Prostate Cancer.”
Urology. 67(5):
1007-1011.
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MT Milano, MC Garofalo,
SJ Chmura, K Farrey, C
Rash, R Heimann, and AB Jani. 2006. “Intensity
Modulated Radiation Therapy (IMRT) for Stomach Cancer: Early Clinical Outcome
and Dosimetric Comparison.” British
Journal of Radiology. 79(942):
497-503.
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AB Jani and J Gratzle.
2006 “Biochemical Control Impact of Hormone Therapy Adjuvant to
Radiotherapy in Different Prostate Cancer Settings.” American Journal of
Cancer. 5(3): 193-198.
o AB Jani, A Su, D
Correa, and J Gratzle. 2006.
“Comparison of Late
Gastrointestinal and Genitourinary Toxicity of Prostate Cancer Patients
Undergoing Intensity-Modulated versus Conventional Radiotherapy Using
Localized Fields.” Prostate Cancer and Prostatic Diseases. (accepted).
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B Knab, C Rash, K Farrey, and AB Jani.2006. “Intensity-Modulated
Radiotherapy for Neoadjuvant Treatment of Gastric
Cancer.” Medical Dosimetry. (accepted).
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