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Education and Degrees

• Ph.D., Temple University School of Medicine, Philadelphia, Pennsylvania, 1982
• M.S., Purdue University, West Lafayette, Indiana, 1978
• B.S., University of Maryland, College Park, Maryland, 1976

Training

• Research Fellow, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, 1982-5

Special Interests

• Eukaryote oxidative and radiation-induced DNA damage repair mechanisms
• Genomic instability

Committee Memberships

• American Board of Radiology, Task Force for New Item Development, 1994-Present
• American Board of Radiology, Ad Hoc Committee on Radiation Oncology Research Initiatives, 1996-Present
• American Board of Radiology, Radiation Oncology Written Examination Committee, 1999
• Radiation Research Society, Michael Fry Research Award Committee, 1998-9
• Radiation Research Society, Councilor-at-Large, 1996-9

Selected Recent Publications

• Beljanski V, Marzilli LG, Doetsch PW.  DNA damage-processing pathways involved in the eukaryotic cellular response to anticancer DNA cross-linking drugs.  Molecular Pharmacology 65(6): 1496-506; 2004.

• Evert BA, Salmon TB, Song B, Jingjing L, Siede W, Doetsch PW.  Spontaneous DNA damage in Saccharomyces cerevisiae elicits phenotypic properties similar to cancer cells.  Journal of Biological Chemistry 279(21): 22585-94; 2004.

• Hannah M, Chow BL, Morey NJ, Jinks-Robertson S, Doetsch PW, Xiao W.  Involvement of two endonuclease III homologs in the base excision repair pathway for the processing of DNA alkylation damage in Saccharomyces cerevisiae.  DNA Repair  3(1): 51-9; 2004.

• Bregeon D, Doddridge ZA, You HJ, Weiss B, Doetsch PW.  Transcriptional mutagenesis induced by uracil and 8-oxoguanine in Escherichia coli.  Molecular Cell 12(4): 959-70; 2003.

• Meadows KL, Song B, Doetsch PW.  Characterization of AP lyase activities of Saccharomyces cerevisiae Ntg1p and Ntg2p:  implications for biological function.  Nucleic Acids Research 31(19): 5560-7; 2003.

• Morey NJ, Doetsch PW, Jinks-Robertson S.  Delineating the requirements for spontaneous DNA damage resistance pathways in genome maintenance and viability in Saccharomyces cerevisiae.  Genetics 164:  443-55; 2003.

• Doetsch PW.  Translesion synthesis by RNA polymerases: occurrence and biological implications for transcriptional mutagenesis.  Mutation Research 510: 131-40; 2002.

• O’Rourke TW, Doudican NA, Mackereth MD, Doetsch PW, Shadel GS.  Mitochondrial dysfunction due to oxidative mitochondrial DNA damage is reduced through cooperative actions of diverse proteins. Molecular and Cellular Biology 22: 4086-93; 2002.

• Xiao W, Chow BL, Hanna M, Doetsch PW.  Deletion of the MAG1 DNA glycosylase gene suppresses alkylation-induced killing and mutagenesis in yeast cells lacking AP endonucleases. Mutation Research 487: 137-47; 2001.

• Kim J-E, You HJ, Choi J-Y, Doetsch PW, Kim J-S, Chung M-H. NTG2 of Saccharomyces cerevisiae repairs the oxidation products of 8-hydroxy guanine. Biochemical and Biophysical Research Communications 285: 1186-91; 2001.

• Doetsch PW, Morey NJ, Swanson RL, Jinks-Robertson S. Yeast base excision repair:  interconnections and networks.  Progress in Nucleic Acids Research and Molecular Biology 68: 29-39; 2001.

• Venkhataraman R, Donald C, Robinary R, You HJ, Doetsch PW, Kow YK.  Enzymatic processing of DNA containing tandem dihydrouracil by endonucleases III and VIII.  Nucleic Acids Research 29: 407-14; 2001.

• Kaur B, Doetsch PW.  Ultraviolet DNA endonuclease (Uve1p): a structure and strand-specific DNA endonuclease. Biochemistry 39: 5788-96; 2000.

• Doetsch PW. DNA damage, repair and mutagenesis (editorial). Methods 22: 115; 2000.

• You HJ, Viswanathan A, Doetsch PW.  An in vitro technique for determining transcriptional mutagenesis.  Methods 22: 120-6; 2000.

• Alleva JL, Doetsch PW.  The nature of the 5' terminus is a major determinant for DNA processing by Schizosaccharomyces pombe Rad2p, a FEN-1 family nuclease. Nucleic Acids Research 28: 2893-901; 2000.

• Alleva JL, Hurwitz J, Zuo S, Doetsch PW. In vitro reconstitution of the Schizosaccharomyces pombe alternative excision repair pathway. Biochemistry 39: 2659-66; 2000.